hepatocyte growth factor การใช้

• For example, insulin-like growth factor 1, hepatocyte growth factor, and angiogenic effect.
• It is a transcriptional factor that influences the expression of hepatocyte growth factor.
• This cytokine and the hepatocyte growth factor ( HGF ) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor.
• Other angiogenic growth factors that decorin inhibits are angiopoietin, hepatocyte growth factor ( HGF ) and platelet-derived growth factor ( PDGF ).
• Molecular Partners lead candidate in oncology is MP0250, a proprietary multi-DARPin designed to inhibit VEGF and hepatocyte growth factor ( HGF ).
• Approximately 20 % of drug resistance is caused by amplification of the hepatocyte growth factor receptor, which drives ERBB3 dependent activation of PI3K.
• Sema domains also occur in the hepatocyte growth factor receptor ( Uniprot : ), Plexin-A3 ( Uniprot : ) and in viral proteins.
• HGS / HRS ( hepatocyte growth factor-regulated tyrosine kinase substrate ) has been found to bind and counteract the function of this protein.
• Both the overexpression of Met / HGFR, as well as its autocrine activation by co-expression of its hepatocyte growth factor ligand, have been implicated in oncogenesis.
• It has been shown that the N-terminal domains of members of the plasminogen / hepatocyte growth factor family, the apple domains of the C-termini of the domain.
• Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation.
• Induction of Mig-7 expression occurs downstream of Epidermal growth factor / Epidermal growth factor receptor, Cox-2 / PGE-2 or Hepatocyte growth factor / c-Met activation and signalling.
• Pathologically, Pax2 has been demonstrated to activate hepatocyte growth factor ( HGF ) gene promoter, and both have been indicated as playing a role in human prostate cancers.
• SPRY2 is a negative feedback regulator of multiple receptor tyrosine kinases ( RTK's ) including receptors for fibroblast growth factor ( FGF ), and hepatocyte growth factor ( HGF ).
• Matriptase is a type II transmembrane serine protease expressed in most human epithelia, where it is coexpressed with its cognate transmembrane inhibitor, hepatocyte growth factor activator inhibitor ( HAI )-1.
• C-MET is a receptor tyrosine kinase ( RTK ) that is activated by its ligand, hepatocyte growth factor ( HGF ), and is involved in the activation of several cellular processes.
• Dally works as a co-receptor of some secreted signaling molecules as fibroblast growth factor, vascular endothelial growth factor, hepatocyte growth factor and members of the Wnt signaling pathway, TGF-b and Hedgehog families.
• Crizotinib inhibits the " c-Met " / Hepatocyte growth factor receptor ( HGFR ) tyrosine kinase, which is involved in the oncogenesis of a number of other histological forms of malignant neoplasms.
• The treatment was based on a protein called hepatocyte growth factor, or HGF . Previous work has shown HGF can promote liver regeneration and suppress cell death, while blocking a second protein that encourages scar formation.
• This protease has been shown to cleave and activate hepatocyte growth factor / scatter factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors.